自闭症谱系障碍和阿尔茨海默病之间的病理生理学相似之处:治疗可能性
William Thomas Phillips1, Alison P Sheesley2, Joyce Gensberg Schwartz3
1Department of Radiology, UT Health San Antonio, San Antonio, TX, United States.
Frontiers in neuroscience
|February 5, 2026
概括
通过鼻淋巴管排放脑脊液 (CSF) 的损伤可能会将自闭症谱系障碍 (ASD) 和阿尔茨海默病 (AD) 联系起来. 这种功能障碍可能有助于在两种疾病中大脑中异常积聚废蛋白.
科学领域:
- 神经科学是一个神经科学.
- 病理生理学 病理生理学
- 比较医学是一种比较医学.
背景情况:
- 自闭症谱系障碍 (ASD) 和阿尔茨海默病 (AD) 具有病理生理学上的相似之处.
- 脑脊液 (CSF) 排水通道,包括淋巴,周血管和鼻轮通道,对于大脑平衡至关重要.
- 这些排水系统的功能障碍可能是ASD和AD的常见因素.
研究的目的:
- 基于共享的病理生理特征来比较自闭症谱系障碍和阿尔茨海默病.
- 调查脑脊液 (CSF) 淋巴排水减少在ASD和AD发生中的作用.
- 激发通过鼻轮的CSF淋巴排水及其对神经退行性和神经发育障碍的影响的研究.
主要方法:
- 对ASD和AD之间的病理生理特征进行比较分析.
- 审查关于CSF动态,淋巴系统功能和ASD和AD的嗅觉功能障碍的现有研究.
- 识别与中枢神经液排水受损相关的成像和临床标志物.
主要成果:
- 与对照组相比,患有ASD和AD的患者表现出额外轴性CSF增加.
- 在ASD和AD中观察到扩大的周血管空间和淋巴功能障碍的证据.
- 嗅觉功能障碍是ASD和AD个体的常见发现,表明鼻腔CSF排水受损.
结论:
- 通过鼻轮减少的CSF淋巴排水是ASD和AD的潜在共享机制.
- 这种排水障碍可能导致大脑中和粉样蛋白质的异常积累.
- 了解这些重叠的特征可能会导致针对CSF流和废物清理的新型治疗策略.
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