使用可见光光学断层扫描的微流体容器芯片模型的无标签评估显示了血管网络的结构变化
Devin Veerman1,2, Carlos Cuartas-Vélez3, Tarek Gensheimer1
1Applied Stem Cell Technologies, Department of Bioengineering Technologies, TechMed Centre, University of Twente, Enschede, The Netherlands. d.veerman@utwente.nl.
Lab on a chip
|February 5, 2026
概括
光学连贯断层扫描 (OCT) 能够在芯片上对血管网络进行无标签的实时成像. 这项技术可以随着时间的推移监测微血管变化,为临床观察提供有关疾病机制的见解.
科学领域:
- 生物医学工程 生物医学工程
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
背景情况:
- 微血管功能障碍会损害小血管,导致器官损伤,特别是视网膜.
- 目前的器官芯片模型缺乏与临床技术相关的动态成像能力.
- 需要实时无标签成像,用于器官芯片平台研究疾病机制.
研究的目的:
- 为了证明光学连贯断层扫描 (OCT) 在芯片上的血管网络的非侵入性,无标签成像的实用性.
- 建立OCT作为一种在器官芯片模型中量化血管结构动态变化的方法.
- 为了弥合体外模型和临床成像之间的差距,用于研究微血管疾病.
主要方法:
- 开发一个芯片上的容器平台来建模微血管.
- 光学连贯断层扫描 (OCT) 的应用,用于血管网络的实时,非侵入性成像.
- 在正常和疾病相关条件下,在多天内对血管网络的结构变化进行量化.
主要成果:
- 海外国家和地区成功提供了芯片上的血管网络的非侵入性,无标签的成像.
- 检测和量化了血管结构在发育过程中和响应疾病条件的动态变化.
- 图像方法允许在多天内进行监测,提供动态数据.
结论:
- 光学连贯断层扫描 (OCT) 是在芯片上实时监测血管网络的可行工具.
- 海外CT可以为器官芯片模型提供临床相关的动态读取结果.
- 这项技术有可能通过将基于芯片的发现与临床指标相关联,提高对疾病病理生理学的理解.
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