富含多的咖啡叶提取物通过调节屏障完整性,肝内轴和肠道微生物群来缓解高脂肪饮食引起的肠道屏障功能障碍
Suhuan Mei1,2, Qingwei Cao1, Gongping Huang1
1School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, Jiangsu 212013, P.R. China.
Journal of agricultural and food chemistry
|February 5, 2026
概括
咖啡叶提取物 (WEAC) 保护肠道屏障,并减少高脂肪饮食小鼠的炎症. 这种富含多的补充剂改善了代谢健康,平衡了肠道细菌,没有不良影响.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 富含多的咖啡叶提取物 (WEAC) 之前已经证明了表皮屏障的保护.
- 高脂肪饮食 (HFD) 诱导肠道屏障功能障碍和全身炎症.
研究的目的:
- 在C57BL/6小鼠中研究WEAC对HFD诱导损伤的保护作用.
- 评估WEAC对肠道屏障完整性,代谢健康和肠道微生物组合的影响.
主要方法:
- 给小鼠了一个HFD与WEAC补充剂 (100-200 mg/kg·bw).
- 评估的体重,血清和组织TNF-α水平,肠道屏障标记物 (紧密结合蛋白,d-乳酸),肝脏组织学,脂质谱,胆汁酸和肠道微生物组合.
主要成果:
- WEAC降低了体重,血清/组织TNF-α,并改善了肠道屏障的完整性.
- 肝脏健康状况改善,脂质积累减少,脂质概况正常化.
- WEAC调节了肠道微生物群,降低了Firmicutes/Bacteroidetes的比率,并增加了像Akkermansia这样的有益细菌.
结论:
- WEAC可以减轻HFD引起的肠壁损伤和肠肝功能障碍.
- WEAC减少了全身炎症,并稳定了HFD养小鼠的肠道微生物群.
- WEAC是管理新陈代谢健康和肠道完整性的有希望的补充剂.
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