葡萄牙50岁以上人口心力衰竭: PORTHOS研究中的流行率和表型
Rui Baptista1,2,3,4,5, Ana Maria Rodrigues6, Filipa Bernardo7
1Cardiology Department, Unidade Local de Saúde de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
European heart journal
|February 5, 2026
概括
心力衰竭影响了六分之一的50岁以上的葡萄牙成年人,主要是未被诊断的心力衰竭与保存的射出分数 (HFpEF). 通过NT-proBNP查和心声回声扫描进行早期检测对于这个老龄化人口至关重要.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 心力衰竭 (HF) 是一个重大的全球健康挑战,其确切的患病率被各种研究设计和不断变化的诊断标准所掩盖.
- 葡萄牙心力衰竭流行观察研究 (PORTHOS) 是为了解决这一知识缺口而启动的.
研究的目的:
- 确定葡萄牙大陆50岁及以上社区成年人心力衰竭的患病率和表型特征.
- 为了确定与心力衰竭相关的风险因素和人口分布,在这个人群中.
主要方法:
- 一个横截面,以人口为基础的研究,采用两阶段设计.
- 第1阶段涉及随机选择50岁以上的个体,采访并进行N-终端B型亲尿素 (NT-proBNP) 检测.
- 第二阶段包括临床评估,心电图和心声回声检查,针对符合特定NT-proBNP值或报告高血压的个体,以及随机抽样的阴性查结果.
主要成果:
- 该研究估计,葡萄牙成年人≥50.5岁的心力衰竭患病率为16.54%.
- 患病率随着年龄的增长而增加,女性 (21.00%) 的患病率高于男性 (10.47%).
- 保存喷射分数 (HFpEF) 的心力衰竭占病例的93.4%,其中90%以前未被诊断出来. 高FpEF与年龄较大,女性性别,2型糖尿病,心房动和脂质失调有关.
结论:
- 50岁以上的葡萄牙成年人中大约有六分之一患有心力衰竭,主要是HFpEF,并且往往未被诊断出来.
- 这些发现强调了NT-proBNP查与心声回声学相结合的实用性,以提高老龄化人口中HF的早期检测.
- 这种方法对于管理人口中日益增长的心力衰竭负担至关重要.
更多相关视频
07:49Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
2.0K
07:13A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
6.9K
相关概念视频
01:29Heart Failure II: Pathophysiology
952
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
952
01:17Pathophysiology of Heart Failure
3.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.8K
01:27Heart Failure I: Introduction
903
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
903
01:22Heart Failure VI: Adjunct Therapies
348
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
348
01:22Heart Failure Drugs: Diuretics
983
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
983
01:30Heart Failure V: Medical Management
330
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
330