如何分析高死亡率的人群中患者报告的长度结果
Joosje C Baltussen1, Nienke A de Glas1,2, Saskia le Cessie3
1Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.
Journal of the American Geriatrics Society
|February 5, 2026
概括
在癌症患者中分析患者报告的结果 (PROs) 需要仔细选择方法,特别是在考虑死亡率时. 不同的分析方法产生了不同的结果,影响了对生活质量 (QoL) 的临床解释.
科学领域:
- 老年瘤学 老年瘤学
- 健康 结果 研究 研究 结果
- 生物统计学 生物统计学
背景情况:
- 在高死亡率人群中,对患者报告结果 (PROs) 的纵向分析具有挑战性.
- 忽视死亡率可能导致偏见的估计和减少PRO数据的临床解释性.
- 本研究探讨了在随访期间死亡的患者中分析PRO的方法.
研究的目的:
- 讨论和比较分析癌症患者高死亡率的纵向PRO的方法.
- 检查不同分析方法如何影响生活质量 (QoL) 结果的解释.
- 用老年癌症患者提供临床示例.
主要方法:
- 包括年龄≥70岁的癌症成年人,来自前队列.
- 在基线,6个月和12个月使用EuroQoL 5维 (EQ-5D) 工具评估生活质量 (QoL).
- 应用了六种方法:四种用于平均得分的绝对变化,两种用于改变QoL的患者比例.
主要成果:
- 在1218名参与者中,321人 (26%) 在12个月内死亡.
- 只关注幸存者的方法会导致有偏见和难以解释的结果.
- 替代方法 (例如,'while-alive'策略,复合终点) 提供了更完整的QOL视图.
结论:
- 方法的选择显著影响了纵向PRO和相关结论的解释.
- 解决死亡率对于准确的估计和有意义的临床解释至关重要.
- 根据研究问题选择合适的方法对于临床医生和患者来说至关重要.
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