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Updated: Feb 7, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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细胞质聚氨酸结合蛋白调节mRNAs对Pumilio介导衰变的敏感性

Katherine M McKenney1, Carmen Hernandez-Perez1, Elise B Dunshee1

  • 1Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States.

Nucleic acids research
|February 5, 2026
PubMed
概括

聚A结合蛋白 (PABPCs) 通过控制聚A尾部来调节信使RNA (mRNA) 衰变. PABPC水平决定了Pumilio蛋白 (PUM1/2) 如何有效地降解目标mRNA,遵循"金髮女孩原则".

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