线粒体被非离子和发射性推拉类型染色体或其聚合物合物准
Atish Nag1, Priya Rajdev1,2, Supan Roy3
1School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Kolkata-700032, India. psusg2@iacs.res.in.
概括
这项研究引入了一种用于线粒体向的新型非离子聚合物,克服了cationic系统的局限性. 该聚合物促进细胞吸收,线粒体进入和同时成像,为药物输送提供了新的途径.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 细胞生物学 细胞生物学
背景情况:
- 对线粒体的向对于有效的药物递送至关重要,旨在绕过内体捕获.
- 目前的线粒体向策略主要依赖于阳离子材料,限制了选择.
研究的目的:
- 报告一种罕见的线粒体向使用水溶性非离子聚合物.
- 描述一种用于细胞内器官输送和成像的新型非离子聚合物系统.
主要方法:
- 一个附加聚甲基甲酸脊柱的氧乙烯合成.
- 用一种氨基替代的甲烯-单胺 (NMI) 衍生物终止,一个推拉染色体.
- 评估细胞吸收,线粒体膜透和光成像能力.
主要成果:
- 通过非离子聚合物系统证明成功准线粒体.
- NMI染色体促进了细胞吸收和线粒体膜穿越.
- 该系统表现出绿色辐射,用于同时光成像和良好的细胞兼容性.
结论:
- 开发的非离子聚合物系统代表了针对线粒体的药物输送的重大进步.
- 多功能NMI染色体可实现高效的输送,成像和结合,为细胞内疗法开辟了新的可能性.
相关概念视频
Polymers
41.0K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
41.0K
Types of Step-Growth Polymers: Polyesters
2.6K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
2.6K
Peroxisomes and Mitochondria
96.2K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
96.2K
Emission Spectra
76.4K
When solids, liquids, or condensed gases are heated sufficiently, they radiate some of the excess energy as light. Photons produced in this manner have a range of energies, and thereby produce a continuous spectrum in which an unbroken series of wavelengths is present.
76.4K
Conjugated Proteins
28.8K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
28.8K
Mitochondria
20.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.5K


