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Updated: Feb 7, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Published on: June 9, 2017

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机械洞察力G蛋白偏差 κ-阿片类受体信号使用双电荷的纳尔特雷克萨明胺基

Niklas Piet Doering1, Kristina Puls1, Marta Diceglie2

  • 1Department of Biology, Chemistry and Pharmacy, Institute of Pharmacy, Molecular Design Group, Königin-Luise-Str. 2 + 4, Berlin 14195, Germany.

Journal of medicinal chemistry
|February 5, 2026
PubMed
概括

研究人员开发了针对卡帕阿片类受体 (KOR) 的新型化合物,以更安全地缓解疼痛. 这些化合物显示G蛋白偏差,为目前的阿片类药物治疗提供了潜在的替代品,副作用较少.

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