银杏花用于认知障碍和痴呆症
Lisa S Wieland1, Emilie Ludeman2, Yuan Chi3,4,5
1Department of Biochemistry and Cellular and Molecular Biology, Georgetown University Medical Center, Washington, District of Columbia, USA.
The Cochrane database of systematic reviews
|February 5, 2026
概括
银杏花在主观认知投诉和轻度认知障碍 (MCI) 中显示了不确定的益处. 对于痴呆症,它可能会在认知,日常功能和临床状态方面略有改善,但不大增加不良事件.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 基于证据的医学 基于证据的医学
- 草药研究 草药研究
背景情况:
- 痴呆症是一种进展性神经认知障碍,影响认知和日常功能.
- 轻度认知障碍 (MCI) 是痴呆症的一个重要风险因素.
- 目前对痴呆症的治疗方法缺乏治愈或减缓疾病的能力.
研究的目的:
- 为了评估金科比洛巴对认知障碍和痴呆症的疗效和安全性.
- 综合来自随机对照试验 (RCT) 关于银杏花效应的证据.
主要方法:
- 82项随机对照试验 (RCT) 的系统审查和元分析,涉及10,613名参与者.
- 包括的研究将银杏花与安慰剂或其他用于认知问题的治疗方法进行了比较.
- 评估结果包括全球临床状态,认知功能,日常生活活动 (ADL),不良事件 (AE) 和严重不良事件 (SAE).
主要成果:
- 对于主观认知投诉,Ginkgo biloba对全球状态的影响是不确定的;一项研究表明,AE的潜在增加.
- 在轻度认知障碍 (MCI) 中,金科比洛巴在六个月后对全球状态,认知或ADL几乎没有影响.
- 在痴呆症中,金科比洛巴在六个月后在全球状态,认知和ADL方面显示出潜在的小到中等益处,而AE或SAE没有显著增加.
结论:
- 银杏花对主观认知症状和MCI的疗效仍然不确定,短期内可能会增加副作用.
- 对于痴呆症,金科比洛巴可能会在认知功能和日常活动中提供适度的改善,具有普遍有利的安全性.
- 需要进一步的研究来澄清金科比洛巴在管理认知衰退和痴呆症中的作用.
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