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Updated: Feb 7, 2026

Hand Dissection of Caenorhabditis elegans Intestines
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三环抗抑郁药抑制了Caenorhabditis elegans中的睡眠

William J Lee1, Marisa C Petticord1, Joel T Woolley1

  • 1Department of Neurology, and the Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA.

Sleep
|February 5, 2026
PubMed
概括

研究人员选了C. elegans中3,683种化学物质,以寻找减少疾病诱导睡眠 (SIS) 的化合物. 他们发现了23种破坏睡眠的化学物质,包括阿米特利普提林,这表明了调节睡眠的新机制.

关键词:
凯诺哈比迪斯 (Caenorhabditis elegans) 是一个可爱的植物.阿米特里普提林氨基的使用.高通量化学屏幕的使用疾病诱导睡眠引起的睡眠.

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