逆境与生物衰老之间的关系中的性别差异
Julian Mutz1, Luca Di Benedetto1,2, Thole H Hoppen3,4
1Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Aging cell
|February 5, 2026
概括
不利的生活事件对男性和女性的生物衰老有不同的影响. 儿童时期的逆境对女性的影响更大,而成年时期的逆境对男性的影响更大,影响衰老标志物,如脆弱性和握力.
科学领域:
- 老年学是指老年学的学科.
- 心理神经内分泌学心理学
- 流行病学 流行病学
背景情况:
- 生命中的不良事件与加速的生物衰老有关.
- 现有的研究还没有充分阐明逆境时间和生物衰老标志物之间的关系中的性别特异性差异.
研究的目的:
- 调查童年和/或成年期逆境与生物衰老标志物之间的关系中的性别差异.
- 确定逆境暴露的时间 (童年与成年) 是否会改变这些性别特异性关联.
主要方法:
- 利用了来自153,557名英国生物库参与者 (年龄在40-69岁) 的数据.
- 评估了童年/成年期逆境与代谢衰老,虚弱,端粒长度和握力之间的关联.
- 采用分层分析和性别对抗性相互作用测试来评估性别差异.
主要成果:
- 童年逆境与多个衰老标志物有关,主要是女性 (代谢物预测年龄,脆弱,端粒长度,握力).
- 成年时期的逆境与男性的某些衰老标志物 (脆弱性,握力) 有较强的关联.
- 对脆弱性和握力观察到显著的性别-逆境相互作用.
结论:
- 逆境暴露的时间显著塑造生物衰老中的性别差异.
- 女性和男性在不同的生命阶段对逆境表现出明显的脆弱性,影响生物衰老.
- 这些发现强调了在衰老研究中考虑性别和逆境的时间的重要性.
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