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Updated: Feb 7, 2026

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眼内压的眼睛和一般决定因素:双大陆眼睛研究
Jost B Jonas1,2,3,4,5,6,7, Rahul A Jonas8,9, Mukharram M Bikbov10
1Rothschild Foundation Hospital, Paris, France.
Investigative ophthalmology & visual science
|February 5, 2026
概括
眼内压力 (IOP) 读数受到各种因素的影响,包括角膜曲率. 根据这些因素调整IOP测量可以显著改变感知到的正常范围,影响青光眼的诊断.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
- 生物识别仪表是如何使用的
背景情况:
- 眼内压力 (IOP) 是诊断和治疗青光眼的关键指标.
- 精确的内血压测量是必不可少的,但读数可能会受到各种眼睛和全身因素的影响.
- 基于人口的研究提供了关于眼部疾病在不同的人口结构的流行率和决定因素的有价值的见解.
研究的目的:
- 评估各种因素与眼内压力 (IOP) 读数的关联.
- 调查这些关联对IOP测量准确性的影响.
- 根据已识别的影响因素,评估纠正IOP读数的有效性.
主要方法:
- 利用俄罗斯,中国和印度研究的基于人口的数据,包括北京眼睛研究 (BES),乌拉尔眼睛和医学研究 (UEMS),乌拉尔非常古老的研究 (UVOS),乌拉尔儿童眼睛研究 (UCES) 和中印度眼睛和医学研究 (CIEMS).
- 包括总共有35,199只眼睛,来自17,977名年龄在6至100岁之间的个体.
- 在IOP测量和统计分析中采用气肺测量或平面测量,以确定关联并验证更正的IOP值.
主要成果:
- 较高的IOP读数与年轻的年龄,女性性别,农村居住,糖尿病,较高的缩血压,较厚的中角膜厚度 (CCT),较的角膜,较长的轴长度和伪脱皮有关.
- 修正后的IOP值显示与外部验证组有很强的相关性 (UEMS:r2 = 0.85;CIEMS:r2 = 0.80).
- 布兰德-阿尔特曼分析显示,UEMS和CIEMS的平均偏差分别为0.80mmHg和1.51mmHg,纠正IOP的个体间差异显著.
结论:
- 角膜曲率半径成为影响IOP读数的主要眼部决定因素,与许多其他眼部和全身因素一起.
- 根据已识别的关联,对测量IOP读数进行校正,导致"正常"IOP范围的上限存在实质性的个体间差异.
- 这些发现凸显了内脏压力测量的复杂性和临床实践中个性化评估的必要性.
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