背中介导的Shh诱导是需要的,以 axolotl 肢体的再生
Sakiya Yamamoto1, Saya Furukawa1, Ayaka Ohashi1
1Okayama University, Graduate School of Environmental, Life, Natural Science and Technology, Okayama, Japan.
eLife
|February 5, 2026
概括
轴突四肢再生中的背部和腹部细胞接触对于模式形成至关重要. 这种相互作用会诱导Sonic hedgehog (Shh) 表达,这对肢体发育至关重要,涉及WNT10B和FGF2信号传递.
科学领域:
- 发展生物学 发展生物学
- 再生医学是一种再生医学.
- 阿克索洛特生物生物学
背景情况:
- 松鼠 (Ambystoma mexicanum) 具有显著的四肢再生能力.
- 传统上,四肢模式的形成需要细胞接触来自不同的胚芽细胞的方向.
- 这一要求背后的分子机制以前尚不清楚.
研究的目的:
- 阐明了轴突肢体再生中的位置性身份要求的分子基础.
- 调查背部和腹部细胞相互作用在四肢模式中的作用.
- 为了确定参与dorsoventral诱导的模式形成的信号通路.
主要方法:
- 在axolotls中利用了辅助四肢模型.
- 创建了特定位置的叶片,缺乏单向衍生细胞 (前,后,背或腹).
- 分析了基因表达模式,专注于Sonic hedgehog (Shh),WNT10B和FGF2.2. 这些基因表达模式.
主要成果:
- 肢体图案仅在含有背部和腹部衍生细胞的叶片中观察到.
- 发现声波刺 (Shh) 表达需要在胚芽细胞内直接的脊中细胞接触.
- 确定WNT10B (背部) 和FGF2 (腹部) 是调解Shh诱导的关键信号.
结论:
- 脊中细胞接触是启动SH表达在轴突四肢再生期间的关键要求.
- WNT10B和FGF2信号通路为Shh介导的四肢模式建立必要的诱导环境.
- 这项研究为推动肢体再生中的位置性身份的分子机制提供了新的见解.
相关概念视频
Requirements for Human Life
13.9K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
13.9K
Proteins: Dietary Sources and Requirements
1.8K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.8K
Oxygen Requirements and Growth Patterns
1.5K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.5K
Carbohydrates: Dietary Sources and Requirements
1.7K
Carbohydrates are predominantly obtained from plant sources. With the exception of lactose found in milk and insignificant glycogen amounts in meat, most consumed carbohydrates have plant origins. Monosaccharides and disaccharides, or sugars, can be sourced from fruits, honey, milk, sugar cane, and sugar beets. Grains and vegetables are rich in the polysaccharide starch. Two types of polysaccharides provide fiber: cellulose, which is abundant in many vegetables, forms undigestible roughage or...
1.7K
Lipids: Dietary Sources and Requirements
2.1K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.1K
Energy-requiring Steps of Glycolysis
171.8K
Glucose is the source of nearly all energy used by organisms. The first step of converting glucose into usable energy is called glycolysis. Glycolysis occurs in the cytosol of the cell over two phases: an energy-requiring phase and an energy-releasing phase. Over the first three steps, glucose is converted into different forms and attached to two phosphate groups donated by two ATP molecules, resulting in an unstable sugar. In the next two stages, the unstable sugar splits into two sugar...
171.8K


