在加拿大的耐塞夫素耐药性尼塞利亚淋病的总结,2017-24年
Robyn Thorington1, Norman Barairo1, Shelley W Peterson1
1National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
The Journal of antimicrobial chemotherapy
|February 5, 2026
概括
在2017年至2024年期间,在加拿大发现了16例抗塞夫特里亚克森淋病病例. 基因组分析揭示了特定的耐药性标志物,但没有发现广泛的社区传播,这凸显了持续监测的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 尼塞利亚淋病是性传播感染的重要原因之一.
- 抗微生物药物耐药性,特别是对 ceftriaxone 的耐药性,是一个日益严重的全球健康问题.
- 对于耐药性淋病菌株的治疗选择有限.
研究的目的:
- 在加拿大 (2017-2024年) 描述16例抗塞夫特里亚克森淋病病例.
- 研究这些耐药分离物的临床,人口,表型和分子特征.
- 通过植物遗传学分析,评估加拿大分离物彼此和国际菌株的相关性.
主要方法:
- 全基因组测序 (WGS) 在所有16种抗塞夫克松分离物中进行.
- 分离物与国际菌株进行了比较.
- 抗微生物敏感性测试使用了CLSI agar稀释协议.
主要成果:
- 塞夫特里亚克松的最低抑制度 (MIC) 在0.25至2mg/L之间.
- 所有病例都源于生殖器部位,其中有四种可能的治疗失败.
- 十个病例与国际旅行有关,七个属于NG-STAR ST 233克隆复合体.
- 所有的分离物都具有与头素耐药性相关的penA基因 (例如,penA 60.001,penA 121.002).
结论:
- 在2017年至2024年期间,在加拿大发现了16例抗塞夫特里亚克森淋病病例.
- 基因组分析确定了与氨酸耐药性相关的特定penA等位基因.
- 公共卫生调查和基因组数据表明,在人口中进一步传播有限.
- 持续监测至关重要,以监测和预防耐塞夫素耐药性尼塞利亚淋病菌的传播.
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