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黑素作为早期新生儿败血症的支持性生物标志物:一项前性研究
Burçin Kaya1, Emrah Can, Yakup Karakurt
1Author Affiliations: Department of Pediatrics, University of Health Sciences, Bağcılar Training and Research Hospital, Istanbul, Türkiye (Drs Kaya, Karakurt, and Gök); Department of Neonatology, University of Health Sciences, Bağcılar Training and Research Hospital, Istanbul, Türkiye (Prof Can); and Neonatal Chief Nurse, Bağcılar Training and Research Hospital, Istanbul, Türkiye (Ms Öğüt).
在怀疑早期发作的新生儿败血症 (EOS) 的新生儿中,血清黑激素水平较低. 虽然黑激素可能有助于诊断,但它缺乏用于最终确定EOS的特异性.
科学领域:
- 新生儿医学 新生儿医学
- 生物化学 生物化学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 早期发病的新生儿败血症 (EOS) 由于非特异性临床症状而带来诊断挑战.
- 血液培养,黄金标准,可以是错误的负在EOS的情况下.
研究的目的:
- 为了比较预产期新生儿的血清黑激素水平,怀疑EOS与健康对照.
- 为了评估黑激素的诊断性能与EOS的标准炎症标志物相比.
主要方法:
- 在84名终身婴儿 (42名疑似EOS,42名对照) 的前性病例对照研究.
- 通过ELISA在生命24小时内收集血液培养,CBC,CRP和血清黑激素.
- 进行了用于诊断评估的接收器操作特征 (ROC) 分析.
主要成果:
- 与对照组相比,在疑似EOS病例中观察到的平均黑激素水平明显较低 (193.5比231.6ppg/mL,P=.010).
- 在培养阳性和培养负性的EOS病例中,黑色素水平没有显著差异.
- 对疑似EOS的ROC分析显示AUC为0.628;242 pg/mL的截止值具有81%的灵敏度,但只有45.2%的特异性.
结论:
- 在怀疑EOS的新生儿中,血清黑激素水平较低.
- 黑色素对EOS的诊断特异性有限.
- 在新生儿败血症的多式诊断方法中,应该考虑黑素作为支持性标记物.
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