相关实验视频

Updated: Feb 7, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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在没有实验结构的情况下,对计算工具进行系统评估,以预测突变对蛋白质-连接体结合亲和力的影响

Qisheng Pan1,2, Stephanie Portelli1,2, Thanh Binh Nguyen1,2

  • 1The Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, University of Queensland, Cooper Rd, St Lucia, Brisbane, QLD 4067, Australia.

Briefings in bioinformatics
|February 5, 2026
PubMed
概括

预测药物耐药性突变需要了解蛋白质 - 配体结合亲和力变化. 像AlphaFold这样的当前蛋白质模型在评估这些突变时显示性能下降,这表明需要突变意识的计算方法.

关键词:
在AlphaFold2中,我们使用了AlphaFold2.药物耐药性 耐药性 药物耐药性连带亲缘关系的变化变化.误解突变是一种错误的突变.分子建模分子建模绩效评价 绩效评价 绩效评价 绩效评价 绩效评价

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