在主观认知衰退中的陌生气味识别能力
Yu-Hsiang Cheng1, Cheng-Chang Yang2,3, Ming-Jang Chiu4,5,6
1Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 112, Taiwan.
概括
使用不熟悉的刺激的嗅觉记忆对阿尔茨海默氏症类型早期痴呆的检测效果有限. 使用不熟悉刺激的嗅觉识别测试 (ORT-US) 没有有效地区分健康人和痴呆症患者.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 早期发现阿尔茨海默氏症类型痴呆 (DAT) 对于及时干预至关重要.
- 在神经退行性疾病中观察到嗅觉记忆缺陷,但它们在早期DAT检测中的实用性需要进一步调查.
- 现有的嗅觉测试可能会被以前的经验和口头记忆所混,需要使用不熟悉的刺激.
研究的目的:
- 探索嗅觉记忆功能与使用不熟悉的刺激进行早期DAT检测之间的关系.
- 开发和评估使用陌生刺激的嗅觉识别测试 (ORT-US),以识别DAT.的辨别能力.
- 在评估嗅觉功能时,尽量减少像以前经历和口头记忆这样的混因素.
主要方法:
- 一项涉及参与者被分为健康对照 (HC),主观认知衰退 (SCD),轻度认知障碍 (MCI) 和非常轻度DAT组的横截面研究.
- 用不熟悉的刺激 (ORT-US) 进行嗅觉识别测试以评估嗅觉记忆.
- 差异分析 (ANOVA) 和接收机操作员特征分析 (ROC) 用于比较ORT-US得分并评估歧视力.
主要成果:
- 只有在健康对照组和非常温和的DAT组之间才观察到ORT-US得分的显著差异.
- 错误报警得分 (错误识别气味) 有显著差异,而成功得分 (正确识别气味) 则没有.
- 来自ROC分析的曲线下的面积是不令人满意的,这表明对DAT检测的陌生刺激的气味识别的有效性有限.
结论:
- 嗅觉记忆功能与早期DAT检测有关,但使用不熟悉的刺激识别气味具有有限的临床实用性.
- 该ORT-US显示,对有效识别具有DAT.的个人的歧视能力不足.
- 需要进一步的研究来探索其他基于嗅觉的标记物,并完善用于早期DAT检测的测试方法.
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