中性粒细胞和血小板对淋巴细胞的比率作为在即时植入物基础重建后囊收缩的预测标记
Jongwon Kang1, Sungjin Jeong1, Yena Yoon1
1Department of Surgery, Seoul National University College of Medicine, Breast Care Center, Seoul National University Bundang Hospital, Seongnam, Korea.
中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 的升高预测了乳房切除重建后囊收缩风险. 这些全身炎症标志物对接受放射治疗的患者尤为重要.
科学领域:
- 整形外科 整形外科 整形外科
- 在瘤学瘤学.
- 炎症研究 炎症研究
背景情况:
- 囊收缩是乳头节省乳房切除术 (NSM) 与直接植入 (DTI) 重建的常见并发症.
- 系统性炎症标志物在囊收缩发作的作用尚不清楚.
研究的目的:
- 调查手术前系统性炎症标志物,特别是中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 之间的关联,以及在NSM与DTI重建后囊收缩的风险.
主要方法:
- 对376名接受NSM与DTI重建的患者的回顾性审查.
- 患者分为非收缩 (贝克尔等级1-2) 和收缩 (贝克尔等级3-4) 的两组.
- 临床病理变量的分析,包括手术前的NLR和PLR.
主要成果:
- 11.4%的患者发生了3级或4级囊收缩.
- 合同组的放射治疗/化疗率较高,以及手术前NLR和PLR的增加.
- 多变量分析确定了放射治疗,升高的NLR和PLR作为囊收缩的独立风险因素.
结论:
- 术前NLR和PLR升高与囊收缩风险增加有关,特别是在接受放射治疗的患者中.
- 系统性炎症,可能由辐射诱导的纤维化恶化,可以协同促进囊收缩.
- NLR和PLR可以帮助进行手术前风险分层和个性化手术规划,用于NSM与DTI重建.
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