脂水的抽脂术后的塞拉佩帕:对抗纤维菌疗效的证据有限
Agostino Bruno1, Valerio Saccoccio2
1Department of Plastic and Reconstructive Surgery and Burn Center, Sant' Eugenio Hospital and Private Practice, Rome, Italy.
Aesthetic plastic surgery
|February 5, 2026
概括
手术后的塞拉佩普塔酶补充剂没有减少脂质瘤的抽脂后纤维化. 这项研究没有发现组织硬度或患者结果的显著差异,质疑其常规使用.
科学领域:
- 整形外科 整形外科 整形外科
- 生物化学 生物化学
- 医学研究 医学研究
背景情况:
- 手术后纤维化是抽脂后的常见并发症.
- 塞拉佩帕因其抗炎和抗纤维素性质而经验上使用,但证据有限.
- 这项研究研究了塞拉佩普塔斯在降低脂质抽取后纤维化症患者的效果.
研究的目的:
- 评估口服塞拉佩普塔斯在缓解术后纤维化的临床有效性.
- 为了评估塞拉佩普塔斯对下肢脂肪抽后的组织硬,疼痛和强度的影响.
主要方法:
- 一个回顾性,观察性队列研究,涉及50名女性唇患者接受了抽脂.
- 患者每天接受60,000 IU的塞拉佩普塔斯,持续4周,或接受标准治疗.
- 使用定量超声波弹性学 (QUS) 测量组织度,其次要结局包括B模式超声波,VAS疼痛得分和临床强化.
主要成果:
- 在4周或3个月后,塞拉佩普塔斯和对照组之间没有发现组织度的统计学上显著差异.
- 二次性结局,包括纤维变化,疼痛评分和硬化,也没有显示与塞拉佩普塔酶有显著的改善.
- 塞拉佩普塔酶耐受性良好,在研究期间没有报告任何不良事件.
结论:
- 口服塞拉佩普塔酶补充剂没有显示出可测量的有效性,用于预防术后纤维化,在脂质抽取后的脂质.
- 研究结果不支持在这种患者群体中常规使用塞拉佩普塔斯.
- 可能需要进一步的研究来探索 lipedema 患者的替代抗纤维素策略.
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