在膝关节骨关节炎中,积极期望和针疗效之间的关联的大脑功能基础
Ze-Yi Wang1, Cun-Zhi Liu1, Xiao-Ya Wei1
1International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, China.
Brain imaging and behavior
|February 5, 2026
概括
积极的期望通过改变后侧环状皮质 (PCC) / precuneus 中的大脑活动来提高针治疗膝关节关节炎的有效性. 这个大脑区域的大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 类风湿病学 类风湿病学
背景情况:
- 预期对慢性疾病治疗结果产生重大影响.
- 将预期与治疗疗效联系起来的神经机制尚不清楚.
- 膝关节关节炎 (KOA) 是一种慢性疾病,心理因素可能会影响治疗的成功.
研究的目的:
- 为了研究预期的神经功能基础.
- 确定预期如何影响KOA患者针治疗疗效.
- 识别与期望驱动治疗效应相关的大脑区域和网络.
主要方法:
- 90名KOA患者被分为针,假针和等待列表组.
- 收集了神经影像 (fALFF,连接性),WOMAC分数和临床数据.
- 相关性分析检查了基线预期,大脑活动和治疗结果之间的关系.
主要成果:
- 积极的预期与低频波动 (fALFF) 的小幅幅度相关,后侧带带皮层 (PCC) /前皮层的变化.
- 在针组中观察到增强的PCC/precuneus-medial前额叶皮层 (mPFC) 连接,具有积极的预期.
- 这些神经变化 (fALFF,连接性) 特定于针组,并与改善的WOMAC功能有关.
结论:
- 改变PCC/precuneus中的fALFF和增强的PCC/precuneus-mPFC连接是预期对针疗效的影响的神经相关物.
- 积极的期望可能会调节参与疼痛感知和安慰剂反应的大脑网络.
- 了解这些神经机制可以为优化KOA治疗结果的策略提供信息.
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