益生菌Bacillus Clausii 通过氧化应激调节,防止阿莫西西林引起的生殖功能障碍
Nadia A El-Fahla1, Nahla S El-Shenawy2, Noran M Tawfik3
1Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt. nadiaahmed_90@yahoo.com.
Probiotics and antimicrobial proteins
|February 5, 2026
概括
接触阿莫西西林 (AMO) 抗生素会通过增加氧化应激和降低来损害男性生殖健康. 益生菌Bacillus clausii可以防止这些毒性影响,改善生殖健康.
科学领域:
- 生殖毒理学 生殖毒理学
- 微生物学 微生物学
- 环境健康 环境健康
背景情况:
- 抗生素在畜牧业中被广泛使用,导致环境积累和潜在的人类健康风险.
- 新兴研究表明,抗生素可能会破坏男性生殖激素,但机制尚未完全理解.
研究的目的:
- 调查阿莫西西林 (AMO) 暴露对男性生殖健康的影响.
- 为了评估巴西路斯克劳西的保护潜力,以防止AMO诱导的毒性.
主要方法:
- 雄性小鼠被分为四组:对照组,B. clausii,AMO,以及AMO+B. clausii.
- 在45天内,每天通过管进行治疗.
- 评估了血清氧化应激标志物,水平,丸组织学和拉巴胺素 (mTOR) 基因表达的机械标.
主要成果:
- AMO暴露增加了氧化应激,降低了丸水平,诱导丸损伤,并降低了mTOR表达.
- 补充B. clausii可以抵消AMO的负面影响,减少氧化应激标志物,改善水平和丸组织学.
- B. clausii治疗上调了mTOR表达,这表明它具有保护作用.
结论:
- 阿莫西西林通过氧化应激和荷尔蒙干扰对男性生殖健康构成重大风险.
- 细菌克劳西在男性生殖系统中显示出对阿莫西西林毒性的保护作用.
- 益生菌的抗氧化特性和调节mTOR信号的潜力有助于其保护作用.
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