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Updated: Feb 7, 2026

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EGFR突变的间隙异质性:系统性审查和元分析

Diana Ivonne Rodríguez Sánchez1,2, Selin Asli Öztürk1, Olga Maxouri1,2

  • 1Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Molecular diagnosis & therapy
|February 5, 2026
PubMed
概括

表皮生长因子受体 (EGFR) 突变异调发生在16.1%的实体瘤中,影响治疗决策. 这一速率因活检类型,TKI暴露和抗药性发展而有显著差异.

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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