肠道微生物群的动态变化和在高脂肪饮食诱导的肥胖小鼠中识别与炎症相关的生物标志物
Jing Wang1,2, Shan Xie1, Zeqiang Li3
1Chongqing Academy of Animal Science, Chongqing, 402460, China.
Antonie van Leeuwenhoek
|February 5, 2026
概括
高脂肪饮食会改变肠道微生物群,增加有害细菌和炎症. 便移植显示肠道微生物传递与肥胖相关的炎症,Proteus和Escherichia-Shigella与炎症标志物相关.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 肥胖研究 肥胖研究
背景情况:
- 高脂肪饮食 (HFD) 与肥胖和肠道失调有关.
- 肠道微生物群在宿主新陈代谢和炎症中起着至关重要的作用.
- 了解肥胖期间的微生物变化对于治疗策略至关重要.
研究的目的:
- 分析HFD诱导肥胖的动态肠道微生物群变化.
- 通过便微生物种移植 (FMT) 调查与肥胖相关的炎症的传染性.
- 为了确定与炎症相关的关键细菌属.
主要方法:
- 小鼠被养正常或高脂肪饮食12周,定期收集便样本.
- 分析了肠道微生物群的组成和多样性.
- 从肥胖小鼠移植到瘦小鼠的便微生物群移植 (FMT) 进行,以评估炎症传播.
- 相关性分析将细菌属与炎症标志物联系起来.
主要成果:
- 长期的HFD显著减少了肠道微生物群的多样性和丰富性.
- HFD增加了有害属的丰富性,如埃舍里希亚-希格拉和蛋白质.
- 来自肥胖捐赠者的FMT增加了接受者小鼠的炎症.
- 蛋白质和Escherichia-Shigella丰度与炎症标志物有积极的相关性.
结论:
- HFD诱导了肠道微生物群组成和多样性的显著动态变化.
- 肠道微生物群对于传播肥胖相关炎症至关重要.
- 蛋白质和Escherichia-Shigella可以作为肥胖相关疾病的亲炎症生物标志物.
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