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视神经外套直径作为一种实时生物标志物,用于在腹膜刺痛后的外周血补丁疗效:初步报告
Kaissar Sassi1, Rachel Fresquet2, Marie-Lucie Dubois2
1Department of Anesthesiology, CHU de Toulouse, Toulouse, France. kaissar_sassi@yahoo.fr.
Journal of clinical monitoring and computing
|February 5, 2026
概括
视神经外直径 (ONSD) 的超声波测量表明,它是一个有希望的客观工具,用于评估早期外周周周血补丁 (EBP) 对腹腔穿刺后头痛 (PDPH) 的有效性. 在ONSD的0.40毫米变化可能表明成功的早期治疗.
科学领域:
- 麻醉学 麻醉学
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 产后刺痛头痛 (PDPH) 是产科外围麻醉后的一个常见并发症.
- 目前对外周血补丁 (EBP) 疗效的评估依赖于主观疼痛评分.
- 需要客观的,实时的指标,用于早期EBP响应.
研究的目的:
- 通过超声波调查视觉神经外直径 (ONSD) 变化,作为早期EBP反应的客观标记.
- 为了将ONSD变化与PDPH患者的疼痛减轻相关联.
主要方法:
- 前性,单中心的观察性研究.
- 30名患有PDPH的产后患者接受EBP.
- 在 (H0) 之前和 (H2) EBP后2小时以超声波测量ONSD.
- 在ONSD变化 (ΔONSD) 和视觉模拟量表 (VAS) 疼痛评分变化 (ΔVAS) 之间的相关性分析.
- 接收器操作特征 (ROC) 分析以确定诊断值.
主要成果:
- 平均 ΔONSD 是 0.97 ± 0.55 毫米.
- 在 ΔONSD 和疼痛减轻之间存在显著的相关性 (r = -0.64,p < 0.001).
- ROC分析显示了良好的诊断性能 (AUC = 0.96).
- 一个 ΔONSD ≥ 0.40 毫米的值显示了100%的灵敏度和83%的特异性,用于早期改善.
结论:
- 对ONSD的超声波测量可以作为评估PDPH早期EBP反应的可行,非侵入性辅助.
- 确定的0.40毫米变化值是早期治疗成功的有希望的指标.
- 需要进行更大规模的多中心研究来证实可重复性和临床效用.
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