术前炎症标志物作为ERCP后胰腺炎的预测剂:一个回顾性队列研究
Mehmet Fuat Çetin1, Mehmet Emin Gönüllü2, Erman Yekenkurul3
1Faculty of Medicine, Department of General Surgery, Duzce University, Duzce, Turkey. mefuce@gmail.com.
Digestive diseases and sciences
|February 5, 2026
概括
术前中性粒细胞与淋巴细胞比率 (NLR) 和C反应蛋白 (CRP) 水平的升高,以及胰腺管道管道,预测ERCP后胰腺炎 (PEP) 风险. 这些炎症标志物在与其他风险因素相结合时,为PEP提供了适度的预测价值.
科学领域:
- 胃肠病学 胃肠病学
- 临床生物标志物 临床生物标志物
- 医学诊断 医学诊断 医学诊断
背景情况:
- 在ERCP后的胰腺炎 (PEP) 是内镜逆行胆血管瘤造影 (ERCP) 的显著并发症.
- 需要PEP的预测生物标志物来提高患者的安全性和指导临床管理.
- 目前对PEP的风险分层依赖于临床和程序因素.
研究的目的:
- 确定简单易用的手术前生物标志物,以预测ERCP后胰腺炎 (PEP) 的风险.
- 评估手术前炎症标志物,特别是中性粒细胞与淋巴细胞比率 (NLR) 和C反应蛋白 (CRP) 与PEP发展的关联.
- 在接受ERCP的患者中评估NLR和CRP对PEP的独立预测值.
主要方法:
- 对接受ERCP的613名成年患者进行了回顾性单中心研究.
- 收集人口统计数据,并发症,手术细节和手术前实验室参数.
- 分析PEP的发展作为主要结果,并对风险因素进行统计评估,包括胰腺管道管,NLR和CRP.
主要成果:
- 在ERCP后的胰腺炎 (PEP) 发生在8.5%的患者中.
- 胰腺管道管是PEP的重要独立风险因素 (aOR:3.05).
- 术前高的中性粒细胞与淋巴细胞比率 (NLR) (aOR:1.14) 和C反应蛋白 (CRP) (aOR:1.04) 独立地与增加PEP风险相关,尽管具有适度的预测能力 (AUCs 0.64-0.66).
结论:
- 手术前的NLR和CRP水平,以及胰腺管道管,独立地与更高的ERCP后胰腺炎 (PEP) 风险有关.
- 虽然在统计学上显著,但NLR和CRP对PEP的预测强度是温和的.
- 当与已确定的临床和程序因素相结合时,NLR和CRP可以作为PEP程序前风险分层的辅助参数. 建议在前性研究中进一步验证.
相关概念视频
Endoscopic Procedures V: ERCP
3.6K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
3.6K
Inflammatory Response
16.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.8K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
7.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.9K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
606
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
606
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
766
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
766
Inflammatory Response I: Vascular and Cellular
16.6K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.6K


