确定中枢神经系统中MSSA感染的安全有效的Cefazolin剂量方案:利用稀缺的现实数据和PBPK建模

Samuel Dubinsky1, Mark McIntyre2,3, Min-Soo Kim4

  • 1Department of Critical Care, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. sam.dubinsky@nshealth.ca.

概括

塞法林可以有效地治疗中枢神经系统 (中枢神经系统) 感染,这种感染是由对甲素敏感的金黄色葡萄球菌 (MSSA) 引起的. 可能需要更高的剂量或持续输注才能在中枢神经系统中达到足够的药物度.

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