从生物和环境矩阵中选择性薄膜微提取纳普罗,采用基托衍生生物打印聚合物与光检测
Zahra Ayazi1,2, Samira Pashayi Sarnaghi1, Mays Ali Hassooni Al-Najafi1
1Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, P.O. Box 53714-161 Tabriz, Iran. ayazi@azaruniv.ac.ir.
The Analyst
|February 5, 2026
概括
这项研究开发了一种基于基托的新型分子印记聚合物 (MIP) 薄膜,用于选择性纳素 (NAP) 提取. 该方法有效地使用薄膜微提取 (TFME) 和光检测从复杂样品中分离NAP.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 纳普罗 (NAP) 是一种广泛使用的非类固醇抗炎药物 (NSAID),具有潜在的环境和健康影响.
- 在生物流体和环境水等复杂矩阵中精确量化NAP对于治疗药物监测和环境评估至关重要.
- 现有的NAP分析方法经常受到复杂的样本准备,低选择性或高成本的影响.
研究的目的:
- 开发和优化用于从复杂矩阵中分离纳素 (NAP) 的选择性和敏感方法.
- 为定制吸附剂应用合成一种自支的基托衍生分子印记聚合物 (MIP) 单体薄膜.
- 采用选择性薄膜微提取 (TFME) 与光光谱学相结合用于NAP量化.
主要方法:
- 一种基托衍生的MIP单体薄膜的合成.
- 使用场发射扫描电子显微镜 (FESEM) 和里埃变换红外光谱 (FTIR) 进行薄膜的表征.
- 优化TFME参数,包括薄膜大小,脱溶剂,提取/脱时间,盐度和pH值.
- 使用光谱学量化NAP的量化.
主要成果:
- 优化的方法在各种矩阵 (脱离离子水,废水,尿液,唾液) 中在广泛的度范围内表现出极好的线性.
- 低检测极限 (LOD) 和量化极限 (LOQ) 已实现,在脱离离子水中LOD低至2.0 ng mL-1.
- 在复杂的生物和环境样本中证实了高精度 (RSD%<8.0%) 和准确性 (相对恢复率97.5%-108.2%).
结论:
- 开发的奇托-MIP薄膜吸收剂是有效的选择性纳素 (NAP) 通过TFME隔离.
- 该方法提供了一种灵敏,准确和精确的方法,用于在各种现实世界样本中确定NAP.
- 这种技术在环境监测和临床诊断中对NAP的常规分析具有前景.
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