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Updated: Feb 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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药物重定位:将局限性HIV蛋白酶抑制剂安普雷纳维尔转化为强效,选择性和中枢神经系统透性对大麻素受体2的激动剂

Daniel H Haymer1,2, Renn A Duncan1,2, Alice L Rodriguez1,2

  • 1Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

Journal of medicinal chemistry
|February 5, 2026
PubMed
概括

艾滋病毒药物安普雷纳维尔重新作为选择性大麻素受体2 (CB2) 激动剂. 结构-活性关系研究表明,在中枢神经系统暴露时产生强大的CB2激动剂,显示出治疗应用的前景.

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