三级淋巴细胞结构的非侵入性成像评估和胃癌中的免疫疗法反应:一个多中心研究
Zepang Sun1, Zhenhui Li2, M Usman Ahmad3
1Second Affiliated Hospital of Guangzhou Medical University Guangzhou, GuangDong province China.
概括
一种新的计算机断层扫描 (CT) 成像模型,ctTLS,在胃癌中非侵入性地评估三级淋巴体结构 (TLS). 这种工具可以预测患者的存活率和免疫治疗的反应,帮助临床决策.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 三级淋巴体结构 (TLS) 是改善生存和抗癌免疫疗法反应的关键生物标志物.
- 需要对TLS进行非侵入性评估,以更好地分层患者和计划治疗.
研究的目的:
- 开发和验证基于计算机断层扫描 (CT) 图像模型 (ctTLSs) 的计算机断层扫描 (CT) 模型,用于在胃癌 (GC) 中对TLS进行非侵入性评估.
- 评估ctTLSs模型与患者预后和免疫治疗反应的关联.
主要方法:
- 一个ctTLSs评分模型被开发和验证在3,155个GC患者使用免疫组织化学分类TLSs.
- 为了模型的解释性和生物相关性,采用了多omics数据和沙普利值分析.
- 评估了模型对TLS状态,存活率和免疫治疗反应的预测性能.
主要成果:
- 在内部和外部验证队列中,ctTLSs模型在预测TLS状态方面表现出高准确性.
- ctTLS与无病和整体存活率 (P<0.01) 有显著的关联.
- 较高的ctTLS水平与免疫激活和亡相关,并预测了显著的免疫疗法益处,客观响应率从ctTLS类的16.7%增加到53.8%.
结论:
- ctTLSs模型提供了一种可靠的非侵入性方法,用于评估GC中的TLS状态.
- 这种基于成像的方法可以改善预后评估,并指导免疫治疗治疗决策.
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