血栓显微镜MA/R比率的预后价值在预测急性呼吸衰竭患者的死亡率方面
Zhang-Sheng Zhao1, Zhen-Zhen Wang1, Lei Wang1
1Transfusion Medicine Center, Apheresis and Transfusion Therapy Center, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, People's Republic of China.
PloS one
|February 5, 2026
概括
凝血的衡量标准MA/R比率预测了急性呼吸衰竭 (ARF) 的结果. 在ICU入院时,低的MA/R比率表明ARF患者的死亡风险较高.
科学领域:
- 临界护理医学 临界护理医学
- 血液学 血液学 血液学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 血栓形成显微镜 (TEG) 提供了关于凝血状态和凝块强度的见解.
- 来自TEG的MA/R比率是血栓强度的关键指标.
- 急性呼吸衰竭 (ARF) 是一种严重的疾病,死亡率很高.
研究的目的:
- 评估ARF患者TEGMA/R比率的预后值.
- 确定MA/R比率是否可以预测ARF的死亡率和其他不良结果.
- 确定与死亡风险增加相关的MA/R比率的潜在值.
主要方法:
- 对371名进入ICU的ARF患者进行了回顾性分析.
- 根据他们的MA/R比率将患者分为四分之一的分层.
- 使用了考克斯的比例危险回归,受限立方线和卡普兰-梅尔分析.
主要成果:
- 最低的MA/R四分位数 (Q1) 与其他四分位数 (22.1-28.0%) 相比,显示28天死亡率明显更高 (59.8%).
- 在最低的MA/R四分位数中观察到炎症标志物升高.
- MA/R比被确定为死亡率的独立预测指标,风险增加低于9.7.
结论:
- 在ARF中,TEG MA/R比率是一个有价值的预后标志物.
- 在ICU入院时,低的MA/R比率意味着凝血受损,并预测不良结果.
- 这种比率可以快速识别高风险的ARF患者.
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