植物化学组成和多目标生物活动 Crataegus monogyna:LC-MS/MS,DFT,和分子对接方法
Emre Can Buluz1, Handan Saraç2, Ahmet Demirbaş2
1Department of Biotechnology, Institute of Science, Ege University, İzmir, Türkiye.
Chemistry & biodiversity
|February 5, 2026
概括
棘 (Crataegus monogyna) 提取物显示出强大的抗氧化剂和酶抑制特性. 乙醇提取物表现出最高的抗氧化活性,而不同的提取物显示出治疗神经和代谢疾病的前景.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 计算化学的计算化学
背景情况:
- Crataegus monogyna (棘) 传统上用于各种健康状况.
- 了解其生物活性化合物及其机制对于验证其治疗潜力至关重要.
研究的目的:
- 分析不同Crataegus monogyna提取物的抗氧化和酶抑制特性.
- 用LC-MS/MS.来确定这些提取物的植物化学特征.
- 在神经和代谢疾病中通过体外和in silico方法研究棘提取物的治疗潜力.
主要方法:
- 使用乙,乙醇和水提取Crataegus monogyna的方法.
- 总和黄含量的量测量.
- 使用DPPH,ABTS,CUPRAC,FRAP和聚烯测试来评估抗氧化活性.
- 对乙胆酶 (AChE),丁胆酶 (BChE),铁酶,氨酶和葡萄糖酶的酶抑制的评估.
- 通过LC-MS/MS进行植物化学分析.
- 在使用密度函数理论 (DFT) 和分子对接的分析中.
主要成果:
- 乙醇提取物表现出最高的和黄类总含量,以及在多个测试中具有卓越的抗氧化能力.
- 乙醇提取物显示出最有效的乙烯基胆化酶 (AChE) 抑制,而酸盐提取物则最有效地对抗丁烯基胆化酶 (BChE).
- 水提取物表现出最强的铁酶抑制,所有提取物通过糖酶和葡萄糖酶抑制显示出抗糖尿病潜力.
结论:
- Crataegus monogyna 提取物具有显著的抗氧化剂和酶抑制活性,支持它们的传统医疗用途.
- 这些发现突出了棘提取物作为神经退行性疾病和糖尿病新型治疗剂的来源的潜力.
- 综合的植物化学,体外和内分析提供了对棘生物活性的全面了解.
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