强化学习指导细分任何模型的MRI前列腺和主导性前列腺内病变的自我细分
Jingchu Chen1, Mingzhe Hu2, Mojtaba Safari3
1Department of Radiation Oncology and Winship Cancer Institute, Emory University, 36 Linden Ave NE, Atlanta, Georgia, 30308, UNITED STATES.
Physics in medicine and biology
|February 5, 2026
概括
这项研究引入了一种自动管道,用于在MRI上对前列腺和主导性前列腺内病变 (DIL) 进行细分,从而改善前列腺癌治疗计划. 该方法在前列腺细分方面实现了高准确度和强大的DILs检测.
科学领域:
- 医疗成像医学成像
- 在瘤学中使用人工智能
- 辐射治疗计划 辐射治疗计划
背景情况:
- 在MRI上精确细分前列腺和主导性前列腺内病变 (DILs),对于前列腺癌放射治疗至关重要.
- DIL细分的挑战包括小数据集,机构偏见和可变成像协议.
- 现有的方法通常依赖于手动提示,限制了自动化.
研究的目的:
- 开发一个完全自动化的管道,用于在MRI上对前列腺和DIL进行细分.
- 将本地化网络与微调的分段任何模型 (SAM) 集成.
- 在多机构数据集上评估自动化细分管道的性能.
主要方法:
- 开发了一个两阶段的管道: (1) 一个基于强化学习的本地化网络用于界限框预测,以及 (2) 一个微调的SAM模型用于细分.
- 使用了两个大型数据集:PI-CAI (1476名患者) 和癌症成像档案 (803名患者).
- 性能被评估使用子相似度系数 (DSC),交叉线 (IoU) 和检测率,并根据病变体积分层分析.
主要成果:
- 该管道实现了前列腺细分的高精度 (平均DSC:0.896,平均IOU:0.818).
- 对于DIL细分,平均DSC为0.592,平均IOU为0.446,检测率为89%.
- 性能在不同损伤量中保持强,表明可概括性.
结论:
- 成功开发了一种用于MRI前列腺和DIL细分的全自动化框架.
- 综合方法在各种数据集和病变特征中显示出强大的性能.
- 这种方法具有显著的潜力,可以提高前列腺癌放射治疗规划中的临床工作流程.
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