在变性青少年中发生青春期阻塞后的成长
Jesus Domingez-Riscart1, Ana García-Zarzuela1, Blanca Romero-Sayago2
1Unidad de Endocrinologia Pediátrica, Servicio de Pediatría, Hospital Universitario Puerta del Mar, Cádiz, España; Instituto de Investigación e Innovación Biomédica de Cádiz (INIBICA), Cádiz, España.
概括
对于跨性别青年来说,青春期阻断疗法可以降低身高和生长速度. 这种效应在变性女孩中比在变性男孩中更为明显,在关键的成长时期影响他们的身体发育.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 青少年医学 青少年医学
- 确认性别的护理
背景情况:
- 变性青少年经历了由青春期变化加剧的性别障碍症.
- 淋巴激素释放激素激动剂 (GnRHa) 用于暂停青春期,允许时间进行身份探索.
- 已知的GnRHa副作用是对生长速度和最终身高的潜在影响.
研究的目的:
- 评估青春期阻断治疗对跨性别儿童和青少年生长速度的影响.
- 为了比较接受 GnRHa 治疗的跨性别男孩和女孩之间的生长参数.
主要方法:
- 纵向研究设计,每六个月进行人体测量和实验室测量.
- 数据收集在开始青春期封锁之前的一年和两年后的数据.
- 统计分析包括威尔科克森签名等级和U-曼惠特尼测试,以比较生长速度和身高标准偏差.
主要成果:
- 研究了55名跨性别青少年 (平均年龄为11.8岁).
- 随着青春期阻塞持续时间的延长,观察到身高和生长速度 (厘米和SD) 的下降.
- 与跨性别男孩相比,跨性别女孩在身高SD中呈现出统计学上显著的较大下降.
结论:
- 青春期封锁导致变性青少年的身高和生长速度下降.
- 变性女孩的身高和生长速度的减少比变性男孩更为显著.
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