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Yu-Hsuan Yeh¹, Shannon J Sirk²

¹Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA; Chan Zuckerberg Biohub, Chicago, IL, USA.

Current opinion in microbiology

|February 5, 2026

概括

研究人员正在开发合成生物学工具箱,以设计非模型细菌,如 Bacteroides 属中的细菌,用于治疗应用. 这使得这些细菌可以用作活药和诊断.

科学领域:

合成生物学合成生物学
微生物工程微生物工程
细菌学细菌学是一门学科.

背景情况:

人类健康应用的工程细菌有着悠久的历史,主要专注于像大肠杆菌 (Escherichia coli) 这样的模型生物.
最近的兴趣正在转向使用非模型共生和益生菌作为工程生物治疗和诊断.
操纵新型细菌物种往往需要专门的工具,这些工具超出了研究过的生物体所能获得的工具.

研究的目的:

介绍开发非模型细菌菌株的合成生物学工具箱的策略.
为研究人员提供与研究不足的细菌物种工作所需的分子生物学框架.
举个例子,使用工程技术的进步来说明开发管道中的 Bacteroides 属.

主要方法:

突出创造合成生物学工具箱的策略.
专注于Bacteroides属作为管道开发的案例研究.
讨论工程非模型细菌的分子生物学框架.

主要成果:

为新型细菌物种构建遗传和代谢操纵工具的证明方法.
提供了适用于各种研究不足的细菌菌株的框架.
在 Bacteroides 属中展示了成功的工程策略.

结论:

合成生物学工具箱对于推进用于健康应用的非模型细菌的工程至关重要.
提出的策略有助于从共生菌和益生菌菌株开发工程生物治疗和诊断.
工程 Bacteroides 属作为一个模型,为其他研究不足的细菌建立类似的管道.

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