宏观和显微特征表明结肠腺癌的血清入侵
Chalisa Wongcharoen1, Saowalak Hunnangkul2, Ananya Pongpaibul3
1Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Pathology, Banpong Hospital, Ministry of Public Health, Ratchaburi, Thailand.
Annals of diagnostic pathology
|February 5, 2026
概括
准确的结肠腺癌的分期需要仔细的粗体检查. 不规则的血清和可见的瘤透是血清入侵 (pT4) 的关键预测指标,指导准确的病理评估.
科学领域:
- 胃肠道病理 胃肠道病理
- 手术瘤学手术瘤学
- 癌症的分期 癌症的分期
背景情况:
- 结肠腺癌是一个重大的全球健康挑战.
- 精确检测血清侵袭 (pT4) 对于患者的预后至关重要.
- 不一致的量化协议使得血清侵袭的诊断变得复杂.
研究的目的:
- 在结肠腺癌中识别血清性侵袭的宏观预测因素.
- 为了确定精确分期所需的瘤块的最小数量.
- 在Siriraj医院评估pT4结肠腺癌的频率.
主要方法:
- 对218例结肠腺癌病例的回顾性审查.
- 胃肠道病理学家评估了宏观特征和临床记录.
- 宏观发现与组织病理学评估的相关性 (AJCC第8版).
主要成果:
- pT4的发病率为20.2% (pT4a:14.7%,pT4b:5.5%). 在这些人中,pT4的发病率为0.2%.
- 不规则的血清 (aOR:7.03) 和宏观的血清透 (aOR:48.76) 是pT4a的重要预测因素.
- 从瘤-血清接口提交至少两个块可确保可靠的分期.
结论:
- pT4率与国际基准可比.
- 不规则的血清和宏观的血清透是pT4a的可靠指标.
- 建议进行细致的粗体检查和充分的组织采样 (至少两块) 以获得最佳的分期准确度.
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