植物化学表征和Lycopodium serratum var.的多目标保护作用 长长的皮皮质体对抗经期障碍,经期障碍
Yi-Fen Chiang1, Cheng-Pei Chung2, Ko-Chieh Huang1
1School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110301, Taiwan.
概括
Lycopodium serratum提取物 (LS) 通过放松子宫肌肉并减少炎症和氧化应激,有效地减少月经疼痛. 乙酸乙烯分量 (LSE-EA) 显示为治疗更年障碍最有前途的.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 原发性经期障碍包括异常的子宫收缩,炎症和氧化应激,影响生活质量.
- 这种植物叫做Lycopodium serratum var. longipetiolatum (LS),一个台湾,传统上用于月经障碍,但其机制尚不清楚.
研究的目的:
- 为了识别LS提取物的化学成分.
- 评估LS的子宫放松剂和抗感应作用.
- 阐明背后的分子机制的LS对失经症的影响.
主要方法:
- 对化合物的LS分数 (LSE-EA,LSE-BuOH,LSE-H2O) 的LC-MS/MS分析.
- 在小鼠身上进行了ex vivo子宫收缩测试和in vivo疼痛模型.
- 西方斑块,生化和病理学分析,以评估分子途径.
主要成果:
- 乙酸乙烯分量 (LSE-EA) 显示出强大的抑制子宫收缩和疼痛.
- 确定的主要化合物包括酸,咖啡酸和酸.
- LSE-EA降低了催产素受体 (OTR),肌轻链激酶 (MLCK),TLR-4/NF-κB/COX-2,ERK和IL-6的下调,同时减少了氧化应激标志物.
结论:
- LS提取物通过抑制依赖的子宫收缩,炎症和氧化应激来缓解经期不良.
- 通过氧化还原介导机制,LSE-EA是一种有前途的治疗分离物,用于通过氧化还原介导机制来控制经经期不良.
关键词:
的流入的流入.经期不良症 经期不良症 经期不良症这种植物叫做Lycopodium serratum var. 长时间的ipetiolatum.氧化应激是一种氧化应激.植物化学分析 植物化学分析子宫收缩是什么意思子宫收缩更多相关视频
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