肠道微生物群对补充食物来源的反应因牛奶养类型而异
B M Perrett1, K Miliku2, T J Moraes3
1Faculty of Kinesiology, University of New Brunswick, Fredericton, New Brunswick, Canada.
Clinical nutrition (Edinburgh, Scotland)
|February 5, 2026
概括
婴儿固体食物来源影响肠道微生物群的多样性,特别是在配方奶粉养的婴儿中. 母乳可能具有保护作用,这凸显了个性化婴儿营养策略的必要性.
科学领域:
- 微生物组研究的研究.
- 婴儿营养 婴儿营养
- 主体-微生物相互作用
背景情况:
- 幼儿营养显著影响婴儿肠道微生物群和长期健康.
- 不同的固体食物来源 (自制,商业,混合) 对婴儿肠道微生物组的影响仍未得到充分研究.
研究的目的:
- 调查6个月的固体食物来源与1岁的婴儿肠道微生物群多样性和组成之间的关系.
- 为了确定这些关系是否因牛奶养类型而改变.
主要方法:
- 加拿大健康婴儿纵向发育 (CHILD) 队列的二次分析.
- 一年后的便样本的16S rRNA测序,在6个月后评估固体食物来源.
- 统计分析包括一般化的线性模型,PERMANOVA和MaAsLin2,调整共变量并检查按牛奶养类型的效果修改.
主要成果:
- 固体食物来源解释了肠道微生物群的最小变异性 (0.53%).
- 配方奶粉养的婴儿显示出最显著的差异:自制/混合食品与6个月后更高的Firmicutes和Turicibacteraceae有关.
- 在1岁时,与商业食品相比,在自制食品上奶粉的婴儿改变了微生物多样性 (丰富度更高,均度更低). 在母乳养或断奶的婴儿中没有观察到显著的影响.
结论:
- 固体食物来源是婴儿肠道微生物群变异的一个未被认可的因素,其影响取决于牛奶养类型.
- 与母乳养婴儿相比,配方奶粉养的婴儿对补充食物来源的敏感性更大.
- 这些发现支持量身定制的婴儿营养策略,强调基于养类型的精准营养.
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