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基于MOF的药物输送系统在瘤免疫治疗中的应用
Jiahao Mi1, Xinran Jiang1, Mengqi Yin1
1Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Colloids and surfaces. B, Biointerfaces
|February 5, 2026
概括
金属有机框架 (MOFs) 通过调节瘤微环境 (TME) 来显示瘤免疫治疗的前景. 本综述探讨了MOF特征,TME调制以及用于增强癌症治疗的协同疗法.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 瘤免疫疗法激活免疫系统,但面临着瘤微环境 (TME) 的挑战.
- 金属有机框架 (MOF) 具有独特的特性,如高孔径性和可调节的结构,用于药物输送.
- 正在探索MOFs作为先进的载体,以克服癌症治疗中的TME障碍.
研究的目的:
- 提供MOF特征和合成的全面概述.
- 阐明基于MOF的药物递送机制,用于瘤免疫治疗中的TME调制.
- 讨论MOF与各种癌症治疗方式的协同作用潜力.
主要方法:
- 审查基本的MOF属性,包括结构属性和合成.
- 针对TME的基于MOF的药物输送系统的分析.
- 探索与化疗,放射治疗,光动力疗法,声动力疗法,化学动力疗法,光热疗法和微波疗法的协同应用.
主要成果:
- 可以将MOFs设计为复杂的药物载体,以克服与TME相关的免疫治疗限制.
- 结合基于MOF的交付与其他疗法的协同效应策略显示出增强治疗结果的潜力.
- 这项研究强调了MOF在解决癌症治疗多个方面的多功能性.
结论:
- 基于MOF的药物递送系统是通过向TME来增强瘤免疫治疗的有希望的策略.
- 需要进一步的研究和开发来解决与癌症治疗中MOF应用相关的临床挑战.
- MOF与多种治疗方式的整合为更有效和个性化的癌症疗法提供了途径.
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