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Updated: Feb 7, 2026

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在Murchita utpalashatpalaghrita中对piperine的稳定性评估进行LCMS方法的验证
Ashutosh Gupta1, Moumita Saha1, Abhishek Ravindra Malandkar2
1Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Journal of Ayurveda and integrative medicine
|February 5, 2026
概括
艾尔维达的murchita工艺,用于净化油脂,令人惊地增强了长期稳定性的piperine,一个关键的化合物在Utpalashatphala ghrita. 这种净化方法提高了尽管初始降解的piperine的稳定性.
科学领域:
- 艾尔韦达医学是一种医药.
- 药理学 药理学是指药理学的学科.
- 分析化学是一种分析化学.
背景情况:
- 乌特帕拉沙特法拉格里塔 (USG) 是一种阿育吠陀配方,其活性成分是皮佩林.
- 墨奇塔工艺是一种阿育吠陀的脂质 (油脂/油脂) 净化技术.
- 了解在murchita过程中和之后的piperine稳定性对于阿育吠陀医学的疗效至关重要.
研究的目的:
- 开发和验证一种LC-MS方法来评估piperine的稳定性.
- 为了量化乌特帕拉沙特法拉格里塔 (Utpalashatphala ghrita) 在murchita过程之前和之后的piperine含量.
主要方法:
- 采用了一种LC-MS系统,具有喷射电离电离和离子陷分析仪.
- 分析使用多重反应监测 (MRM) 模式进行.
- 根据ICH Q2 (R2) 准则,LC-MS方法经过验证,使用水和甲醇中的甲酸移动相.
主要成果:
- 开发的LC-MS方法证明了准确性,精度和线性 (0.5-32μg/mL),LOQ为125 ng/mL,运行时间为10分钟.
- 默奇塔工艺导致皮佩林的26%降解.
- 与未经加工的USG相比,Piperin在Murchita-Utpalashatphala ghrita (M-USG) 中表现出增强的稳定性.
结论:
- 穆尔奇塔工艺显著提高了乌特帕拉沙特帕拉格里塔 (Utpalashatphala ghrita) 中皮佩林的长期稳定性.
- 这一发现对含有piperine的阿育吠陀药物的配方和保质期有影响.
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