一项基于COM-B的身体活动行为改变干预试验的试点随机对照试验的结果,该干预是在新诊断患有多发性硬化症的人身上进行的
Trinh Lt Huynh1, Robert W Motl2
1Department of Medicine, Division of Academic Internal Medicine and Geriatrics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Multiple sclerosis and related disorders
|February 5, 2026
概括
一项新的行为干预措施有效地增加了多发性硬化症 (PNDwMS) 新诊断的人的体力活动 (PA) 和改善了心理健康. 这种基于COM-B模型的方法对PNDwMS管理具有前景.
科学领域:
- 神经学 神经学
- 行为科学 行为科学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 诊断对维持身体活动 (PA) 提出了挑战.
- 行为干预可以促进PA,但需要针对新诊断的个体量身定制的方法.
- 能力-机会-动机-行为 (COM-B) 模型为设计有效的行为改变策略提供了一个框架.
研究的目的:
- 评估基于COM-B模型的行为干预措施在新诊断患有多发性硬化症 (PNDwMS) 的人群中促进PA的疗效.
- 评估干预对二次结果的影响,包括疲劳,抑郁,焦虑和与健康有关的生活质量 (HRQOL).
主要方法:
- 试点随机对照试验 (RCT) 使用50个PNDwMS随机对付PA干预或等候名单控制 (WLC).
- 通过在线指导和新闻通讯,在16周内进行了干预.
- 主要结果:设备测量和自我报告的PA. 二次结果:疲劳,抑郁,焦虑,HRQOL.
主要成果:
- 在干预组中观察到中度至强度的PA (MVPA) 和自我报告的PA (IPAQ) 的显著改善.
- 该干预还导致了抑郁症 (HADS-D) 和HRQOL (SF-12) 的精神成分摘要 (MCS) 的显著改善.
- 在WLC组中,没有注意到主要或次要结果的显著变化.
结论:
- 基于COM-B的行为干预表明了在增加PNDwMS中PA的初步有效性.
- 该干预措施对这一群体的心理健康结果产生了积极的影响,包括抑郁症和HRQOL.
- 这些发现支持将这种干预作为管理PNDwMS的工具.
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