儿童的第一个脱髓化攻击:一个十二岁的单中心队列
Alessandro Santagostino Barbone1, Thea Giacomini2, Silvia Casabona1
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetic and Maternal Infantile Sciences, University of Genova, Genova, Italy.
Multiple sclerosis and related disorders
|February 5, 2026
概括
在儿童中诊断获得性脱髓化综合征 (ADS) 是复杂的. 这项研究强调了儿科多发性硬化症 (MS) 和髓-氧基细胞蛋白抗体相关疾病 (MOGAD) 的初始表现如何不同,有助于准确的诊断和治疗.
科学领域:
- 儿科神经学 儿科神经学
- 神经免疫学 神经免疫学
- 脱线性疾病 脱线性疾病
背景情况:
- 由于症状重叠,儿童获得的脱髓化综合征 (ADS) 存在诊断挑战.
- 对于有效的治疗和预后,准确区分单相性和复发性疾病,如儿科发病多发性硬化症 (POMS),髓-氧基细胞糖蛋白抗体相关疾病 (MOGAD) 和血清阴性ADS至关重要.
研究的目的:
- 描述儿科ADS的初始表现.
- 评估随着时间的推移的诊断演变,以指导治疗决策.
主要方法:
- 在第三级儿科中心对59名患有ADS的儿童 (2012-2024) 进行回顾性分析.
- 最初的诊断包括MS,ADEM,CIS,ON,NMOSD或"不确定的". 最终的诊断是MS,MOGAD或"其他".
- 分析人口统计,临床,MRI,CSF数据和结果,并进行统计比较.
主要成果:
- 发病时的年龄较大,没有先前的感染,以及特定的MRI发现 (周腹腔/腔病变,小脑病变) 在MS组中更为常见.
- 年轻的年龄,先前的感染,发烧,易怒和皮质干扰与MOGAD有关.
- 29%的最终MS病例最初被诊断为CIS或ON;没有ADEM病例转化为MS. "其他"ADS患者表现出更严重的初始残疾.
结论:
- 儿科ADS在发病时表现出异质性.
- 精确的急性管理和纵向随访对于完善儿童脱髓化疾病的诊断和指导治疗至关重要.
相关概念视频
Acid Attack on Concrete
769
When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
The rate at which hydrogen...
769
Sulfate Attack on Concrete
752
Sulfate attack on concrete is a deterioration process characterized by a whitish discoloration beginning at the edges and corners, accompanied by cracking and spalling. This phenomenon occurs when sulfates react with the components of hardened concrete, forming compounds like calcium sulfate and calcium sulfoaluminate which occupy more space than the substances they replace, causing the concrete to expand and disrupt.
Sulfates from sources like soil, groundwater, or industrial effluents...
Sulfates from sources like soil, groundwater, or industrial effluents...
752
Lattice Centering and Coordination Number
11.7K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.7K
Center of Gravity
6.7K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
Center of Gravity
2.2K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
Center of Mass
2.0K
The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K


