儿童Toxoplasma gondii,精神病经历和灰质体积之间的关联:基于人口的队列研究
Jehanita Jesuthasan1, Kate Merritt2, Francesca Solmi2
1Division of Psychiatry, University College London, London, UK; Institute of Cognitive Neuroscience, University College London, London, UK.
Schizophrenia research
|February 5, 2026
概括
儿童时期的Toxoplasma gondii感染与以后的精神病体验或大脑体积无关. 孕期猫暴露与较高的T. gondii水平相关,这表明精神分裂症谱系障碍的潜在危险因素.
科学领域:
- 神经科学是一个神经科学.
- 传染病流行病学 传染病流行病学
- 精神病学是一个精神病学.
背景情况:
- 毒素菌 (T. gondii) 感染是精神分裂症的潜在危险因素.
- 之前的研究经常使用猫养猫作为T. gondii暴露的代理.
- 甘地菌,精神病体验和大脑结构之间的关系需要进一步调查.
研究的目的:
- 检查血清T. gondii水平与个人随后的精神病体验 (PE) 之间的关联.
- 为了研究T. gondii血清学和大脑灰质体积之间的联系.
- 探索在不同生命阶段拥有猫和T. gondii血清学之间的关系.
主要方法:
- 利用了来自于3542名参与者的艾文长度父母与儿童研究 (ALSPAC) 的数据.
- 评估了儿童时期的血清T. gondii水平和18岁时的PE.
- 在20岁时在MRI扫描 (N=334) 上使用基于voxel的形态测量来测量灰质体积.
- 分析了孕期和童年期间拥有猫的数据.
主要成果:
- 儿童时期的血清T. gondii水平与18岁时的PEs或精神疾病没有显著相关.
- 在神经成像子组中,T. gondii水平和灰质体积之间没有发现任何关联.
- 怀孕期间接触猫与青春期更高的T. gondii水平有关 (p=0.033),但儿童猫暴露没有 (p=0.310).
结论:
- 儿童T. gondii感染并不是PEs或大脑体积变化的重要预测因素.
- 怀孕期间拥有猫可能是T. gondii暴露的更相关的代理,而不是童年所有权.
- 未来对T. gondii和精神分裂症的研究应该考虑孕期猫暴露和血清学数据.
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