相关实验视频

Updated: Feb 7, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

从葡萄藤 (Vitis vinifera) 提取的维素B增强了记忆功能和神经保护作用,在斯科波胺诱导的记忆障碍小鼠中发挥了作用

Won Seok Kim¹, Jeongyoon Choi², Seong-Seop Kim²

¹Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Department of Life Science, Korea University, Seoul 02841, Republic of Korea.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|February 5, 2026

概括

维他素B是一种来自葡萄酒的化合物,对阿尔茨海默氏症 (AD) 有希望. 它通过保护脑细胞和增强突触可塑性,改善了AD小鼠模型中的记忆和认知功能.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

阿尔茨海默病 (AD) 涉及认知能力下降,记忆力丧失和突触可塑性受损.
维素B是一种白醇四聚合物,具有抗氧化和神经保护性质.
在AD模型中Vitisin B的认知效应需要进一步研究.

研究的目的:

在阿尔茨海默氏病模型中研究维素B的神经保护和前认知作用.
评估Vitisin B对细胞活力,认知功能和突触可塑性的影响.

主要方法:

在体外:SH-SY5Y细胞接受了 scopolamine 和 Vitisin B. 的治疗.
在体内:斯科波胺诱导的AD小鼠模型与系统和脑内内维素B的管理.
认知评估包括Y迷宫,开放场地,新型对象识别和被动回避测试.

主要成果:

维素B在体外增强了细胞活力.
在体内,Vitisin B改善了空间工作记忆,使探索活动正常化,并增强了识别和长期记忆.
治疗恢复了认知功能,减少了胆固醇缺乏,增加了海马BDNF,改善了突触可塑性.

结论:

在AD模型中,Vitisin B显示出显著的认知和神经保护作用.
系统性和直接给大脑的Vitisin B都是有效的.
维素B具有作为阿尔茨海默病治疗剂的潜力,准胆固醇功能和突触可塑性.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.记忆功能记忆功能记忆功能神经保护是一种神经保护.葡萄酒 (Vitis vinifera) 是一种葡萄酒.在 Vitisin B 中使用.

更多相关视频

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

相关概念视频

System of Memory

System of Memory

Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...

Working Memory

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...

Higher Mental Functions of Brain: Learning and Memory

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...

Long-Term Memory

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...

Traumatic Memory

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...

Repressed Memory

Repressed Memory

Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...