宽带光学光谱 (BOS) 作为对瘤性肠球炎 (NEC) 的非侵入性监测的首次在人体上的试点研究
Ashley C Dodd1, Alison J Lehane1, Anna Lee2
1Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
Journal of pediatric surgery
|February 5, 2026
概括
宽带光学光谱 (BOS) 是一种安全的,非侵入性的工具,可用于早期检测早产婴儿的死性肠球炎 (NEC). 这项研究发现,在中度至重度NEC的婴儿中,BOS测量有显著差异.
科学领域:
- 新生儿医学 新生儿医学
- 生物医学光学 生物医学光学
- 医疗器械开发 医疗器械开发
背景情况:
- 结核性肠球炎 (NEC) 缺乏可靠的早期诊断标记物和预测生物标记物.
- 宽带光学光谱 (BOS) 是一种非侵入性工具,在动物模型中预测NEC方面取得了先前的成功.
- 这项研究报告了BOS在早产婴儿中检测NEC的第一个人体试验.
研究的目的:
- 评估一种新型BOS装置的安全性和可行性,用于对早产婴儿的NEC进行临床评估.
- 为了确定BOS是否能够检测出新生儿中NEC的迹象.
- 评估BOS作为NEC早期查或诊断工具的潜力.
主要方法:
- 使用婴儿专用的BOS探针和光谱仪系统,覆盖350-2500nm检测范围.
- 没有心脏或腹部缺陷的早产婴儿 (<36周孕期) 被纳入.
- 监督机器学习 (支持矢量机器) 分析了来自四个腹部象限的BOS读数.
主要成果:
- 纳入了96名婴儿;BOS测量得到了快速,没有患者伤害或临床干扰.
- 在所有婴儿皮肤色调中,从腹内肠道获得可靠的信号.
- 在NEC发作 (贝尔阶段2/3) 期间,BOS测量显示出明显的差异,并被追溯确定为>90%的灵敏度和特异性.
结论:
- 宽带光学光谱是一种安全,可行和非侵入性技术,用于床边NEC评估.
- 在中度至重度NEC的婴儿中检测到的信号变化表明BOS的早期查和检测潜力.
- BOS显示,它有望改善NEC风险的脆弱早产婴儿的治疗结果.
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