重温MASLD中的肥胖悖论:纵向轨迹分析揭示了时间变化的死亡风险
概括
在代谢功能障碍相关的脂肪性肝病 (MASLD) 中,肥胖生存悖论是复杂的. 在整个成年期保持非肥胖状态与较低的死亡率有关,这挑战了MASLD中肥胖生存益处的概念.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 肥胖是代谢功能障碍相关的脂肪性肝病 (MASLD) 的主要驱动因素.
- 具有悖论的,患有MASLD的肥胖患者比非肥胖个体有更好的生存率.
- 这是一个很棒的节目,这是一个很棒的节目.
- 肥胖生存悖论 肥胖生存悖论
- 在MASLD中,需要使用纵向数据进行进一步调查.
研究的目的:
- 为了调查该事件的发生.
- 肥胖生存悖论 肥胖生存悖论
- 在MASLD.
- 分析身体质量指数 (BMI) 轨迹与MASLD患者死亡风险之间的关联.
主要方法:
- 分析了三大基于人口的MASLD队列 (NHANES III,NHANES 1999-2018,英国生物库).
- 利用多变量调整的受限制立方线模型来评估BMI-死亡率和剂量反应关系.
- 采用隐性类轨迹建模来识别不同的长期BMI模式.
主要成果:
- 成年期中期或晚期肥胖 (BMI > 30) 或MASLD后诊断与降低整体死亡率相关.
- 较高的早期成人BMI与增加的死亡率有关.
- 持续的肥胖和快速的BMI增加与明显更高的死亡率有关,而持续的非肥胖预测风险较低.
结论:
- 肥胖和MASLD结果之间的关系是异质的,这取决于肥胖暴露的时间.
- 长期的BMI轨迹分析表明,肥胖症在MASLD中没有生存优势.
- 在整个成年期保持非肥胖状态与MASLD的整体死亡率较低有关.
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