超过10年的德诺苏马布治疗:随后的治疗和密度计结果
Xi Xiong1, Chun Ho Wong2, Kimberly H Tsoi2
1Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Research Department of Practice and Policy, School of Pharmacy, University College London, London, United Kingdom; Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
在20剂以上的持续denosumab治疗中,根据骨矿物质密度 (BMD) T-score指导,腰椎的BMD进一步增加,并在大腿部保持BMD. 切换到zoledronic acid导致部分BMD损失,而romosozumab只增加了腰椎BMD.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 德诺苏马布是骨质疏松症的关键治疗方法.
- 20剂后的长期治疗策略需要进一步阐明.
- 了解治疗轨迹对于优化骨质疏松症管理至关重要.
研究的目的:
- 描述20个德诺苏马布剂量后的治疗方法.
- 在治疗变化后检查骨矿物质密度 (BMD) 轨迹.
- 为了比较继续使用登苏马布的结果与切换到佐勒龙酸或罗莫苏马布的结果.
主要方法:
- 回顾性单中心队列研究.
- 包括接受≥20次连续代诺苏马布剂量的患者.
- 基于治疗延续或过渡的分析BMD变化.
主要成果:
- 大多数患者 (48/54) 继续服用德诺苏马布,以BMDT分数为指导.
- 持续使用德诺苏马布增加了腰椎和大腿部部的BMD.
- 过渡到佐列龙酸导致部分BMD损失;罗莫苏祖马布仅增加腰椎BMD.
结论:
- 超过20剂的持续使用德诺苏马布对腰椎和大腿部部BMD有效.
- 在20次德诺苏马布剂量后的治疗决策应考虑BMDT分数.
- 没有报告任何不良事件,如非典型的股骨骨折或下巴骨硬化.
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