通过人工智能和分子标记物的协同使用,提高甲状腺病理的诊断精度
Sarah Azad1, Srisai A Turangi2, Anery Patel1
1Department of Internal Medicine, Division of Diabetes, Endocrinology & Metabolism, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
概括
整合人工智能成像与分子测试的不确定性甲状腺结节保持高灵敏度,同时提高诊断准确度和减少不必要的手术. 在临床采用之前需要进一步验证.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 不确定的甲状腺结节带来诊断挑战,通常需要手术.
- 分子测试提供高负预测值 (NPV),但有限的正预测值 (PPV).
- 基于人工智能的成像 (AIBx V2) 和分子测试 (ThyroSeq v3) 是新兴的诊断工具.
研究的目的:
- 为了评估将AIBx V2与ThyroSeq v3集成用于不确定的甲状腺结节的诊断准确性.
- 评估组合方法是否可以提高单个测试的性能.
主要方法:
- 对108个不确定的甲状腺结节进行了回顾性分析.
- 单独使用 AIBx V2,单独使用 ThyroSeq v3 和联合使用 AIBx V2+Mol 的方法进行比较.
- 用于初级分析的外科病理 (n=42);用于现实实践分析剩余的结节.
主要成果:
- 结合的AIBx V2+Mol方法保持了高灵敏度 (0.95),同时提高了特异性.
- 在外科病理学子组中,PPV增加到0.72,在整个队列中增加到0.72.
- 在外科手术的子组中,AUC从0.70提高到0.77,在整个队列中从0.91提高到0.93.
结论:
- 将AIBx V2与ThyroSeq v3集成,可以保持高灵敏度,并增强对未确定的甲状腺结节的特异性和PPV.
- 结合的方法显示了改善诊断准确性的前景.
- 在临床实施之前,需要进行更大规模的验证研究.
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