在现实世界的经验中,在胡卜状细胞再血管化后的结果中存在性别差异
Daniela Mazzaccaro1, Sara Boveri2, Emanuele Girani2
1Operative Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Annals of vascular surgery
|February 5, 2026
概括
这项研究发现,在30天和1年后, carotid endarterectomy (CEA) 或支架 (CAS) 之后,死亡,中风或心肌梗塞没有显著的性别差异. 接受CAS治疗的症状女性的1年生存率较低.
科学领域:
- 心血管外科心血管外科
- 血管外科 血管外科
- 临床结果研究研究
背景情况:
- 冠状动脉狭窄带来了严重的中风风险.
- 冠状动脉内关节切除术 (CEA) 和冠状动脉支架 (CAS) 是主要的重血管化治疗方法.
- 了解基于性别的结果差异对于个性化患者护理至关重要.
研究的目的:
- 在CEA和CAS之后,调查性别对重大不良事件的影响.
- 为了比较经过动脉再血管化的男性和女性患者之间的结果.
- 分析30天和1年的死亡,中风和心肌梗塞的性别特异性风险.
主要方法:
- 从2010年开始对现实世界数据集 (TriNetX) 的回顾性分析.
- 包括接受CEA或CAS治疗心血管狭窄的18岁以上的患者.
- 在症状/无症状和CEA/CAS队列分层进行比较分析.
主要成果:
- 分析了59,340个动脉复血管化手术 (53741个CEA,5599个CAS).
- 在手术后30天,死亡,中风或心肌梗塞没有显著的性别差异.
- 一年后,接受CAS的症状女性的生存率比男性低 (86.7%vs93.8%).
结论:
- 总的来说,在CEA或CAS后30天和1年后,没有观察到主要不良事件的性别差异.
- 值得注意的一项例外是,在用CAS治疗的症状女性中,减少了一年生存时间.
- 这些发现凸显了在治疗接受CAS的女性症状患者时,需要对性别进行特定考虑的需要.
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