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镜头下的Vogt-Koyanagi-Harada疾病:来自多式眼镜成像的见解

Lan Xia¹, Ling Chen², Lingyu Dai¹

¹Ophthalmology Medical Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, Chongqing Branch (Municipality Division) of National Clinical Research Centre for Ocular Diseases, Chongqing, China.

Progress in retinal and eye research

|February 5, 2026

概括

多式眼镜成像 (MMI) 对于诊断和监测Vogt-Koyanagi-Harada (VKH) 疾病至关重要. 这次审查强调了MMI的重点.

科学领域:

眼科医生眼科眼科
免疫学免疫学免疫学
医疗成像医学成像

背景情况:

沃格特-科亚纳吉-哈拉达 (Vogt-Koyanagi-Harada,简称VKH) 疾病是一种多系统的自身免疫性疾病,会影响富含黑色素细胞的组织,主要是胸膜.
目前的VKH诊断和管理在很大程度上依赖于临床观察,对成像生物标志物的有限使用用于分期和治疗决策.

研究的目的:

审查多式眼镜成像 (MMI) 在Vogt-Koyanagi-Harada (VKH) 疾病的诊断,监测和预后中不断变化的作用.
批判性地评估各种眼部成像模式的实用性和局限性,以了解VKH病理生理学和疾病进展.

主要方法:

在VKH中应用彩色底部摄影,光素血管学 (FFA),绿色血管学 (ICGA),光学连贯性断层扫描 (OCT),OCT血管学 (OCTA),底部自光学,B扫描超声波学,超声波生物显微镜和前段摄影的现有文献的全面审查.
与VKH相关的关键成像特征的描述,包括冠状腺加厚,低光暗点,RPE波动和流空隙,与疾病阶段相关.

主要成果:

MMI提供了对VKH疾病活动的补充见解,从亚临床炎症到慢性后果,如子纤维化和胆道缩.
确定的差距包括缺乏复发/缓解的标准化成像标准,前段成像的不足利用,以及对先进技术的可变访问.
提出一个特定阶段的成像框架,以指导所有疾病阶段的VKH评估.

结论:

多式眼镜成像 (MMI) 已成为Vogt-Koyanagi-Harada (VKH) 疾病管理的核心,超越了支持性作用.
未来的方向包括开发定量成像生物标志物,标准化分级系统,并将成像集成到个性化护理的治疗算法中.
加强MMI的使用对于及时干预和预防VKH患者不可逆转的视力损伤至关重要.

关键词:

冠状腺炎冠状腺炎印度氨酸绿色血管学多模式成像技术多模式成像技术光学连贯性断层扫描仪视网膜诊断视网膜诊断视网膜诊断排卵管炎排卵管炎是一种沃格特 - 科亚纳吉 - 哈拉达

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