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Updated: Feb 7, 2026

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使用有线状真菌模型的查策略,用于用于线粒体复合物I缺陷的药物的重新用途

Carole H Sellem1, Nolwenn Bounaix2, Mathilde Logerais1

  • 1Université Paris-Saclay, CNRS, CEA, I2BC UMR 9198, 91190 Gif-sur-Yvette, France.

Life sciences
|February 5, 2026
PubMed
概括

美国食品和药物管理局批准的药物被重新用于治疗线粒体综合体I疾病. 阿尔维林酸盐和达普素化物在真菌,虫和人体模型中有效地挽救了复合I缺乏症,显示出治疗潜力.

关键词:
综合体I 是一个综合体.疾病模型的疾病模型.药物重新定位 药物重新定位线粒体疾病是线粒体疾病.氧化酸化是一种氧化酸化.血清素受体的配体是血清素受体的配体.

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